In the process of high frequency signal transmission, in order to avoid the problem of signal integrity caused by impedance mismatch, an impedance matching self-calibration circuit was designed, which was suitable for high frequency signal transmission. The two point search method was used to detect the resistance of different weights in parallel, with the comparator's comparison results to decide whether to incorporate resistance, so the resistance could be trimmed expectedly. Toreduce the interference of external high frequency signal and remove the input referred parasitic capacitance, theinductance devices were increased. The circuit was powered off after calibration to save the overall power consumption. Compared with the traditional simple parallel or series resistance trimming structure, the proposed structure was suitable for high frequency signal transmission, having high calibration precision and good signal transmission performance. The circuit was designed in TSMC 0.18 μm CMOS process at a supply voltage of 1.8 V. Simulation results showed that the maximum trimming value reached 98.43 Ω. Compared with the expected 100 Ω resistance, the simulation accuracy was 1.57%. The overall performances before and after adding inductors were compared. After adding inductors, the signal reflected energy had been reduce deffectively. So the integrity of signal transmission had been guaranteed.